A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies

Research output: Contribution to journalArticle

Abstract

Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications.

Details

Authors
  • IMBI Project
  • Daniela Perani
  • Leonardo Iaccarino
  • Adriaan A. Lammertsma
  • Albert D. Windhorst
  • Paul Edison
  • Ronald Boellaard
  • Oskar Hansson
  • Agneta Nordberg
  • Andreas H. Jacobs
Organisations
External organisations
  • Vita-Salute San Raffaele University
  • Amsterdam UMC - Vrije Universiteit Amsterdam
  • Imperial College London
  • Academic Medical Center of University of Amsterdam (AMC)
  • Skåne University Hospital
  • Karolinska Institutet
  • University of Münster
  • Johanniter Krankenhaus
  • San Raffaele Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • Amyloid, Neuroinflammation, PET molecular imaging, Protheinopathies, Radiotracers, Tau
Original languageEnglish
JournalAlzheimer's and Dementia
Publication statusE-pub ahead of print - 2019 Jun 21
Publication categoryResearch
Peer-reviewedYes