A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

Research output: Contribution to journalArticle


The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.


  • G Appendino
  • C Della Porta
  • G Conseil
  • Olov Sterner
  • E Mercalli
  • C Dumontet
  • A Di Pietro
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
Original languageEnglish
Pages (from-to)140-142
JournalJournal of Natural Products
Issue number1
Publication statusPublished - 2003
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)