A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.

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A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging. / Su, Jing; Ekman, Carl; Oskolkov, Nikolay; Lahti, Leo; Ström, Kristoffer; Brazma, Alvis; Groop, Leif; Rung, Johan; Hansson, Ola.

In: Skeletal Muscle, Vol. 5, 35, 2015.

Research output: Contribution to journalArticle

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TY - JOUR

T1 - A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.

AU - Su, Jing

AU - Ekman, Carl

AU - Oskolkov, Nikolay

AU - Lahti, Leo

AU - Ström, Kristoffer

AU - Brazma, Alvis

AU - Groop, Leif

AU - Rung, Johan

AU - Hansson, Ola

PY - 2015

Y1 - 2015

N2 - Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational complications and non-homogenous annotation. To address these issues, we have performed a complete re-annotation of public microarray data from human skeletal muscle biopsies and constructed a muscle expression compendium consisting of nearly 3000 samples. The created muscle compendium is a publicly available resource including all curated annotation. Using this data set, we aimed to elucidate the molecular mechanism of muscle aging and to describe how physical exercise may alleviate negative physiological effects.

AB - Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational complications and non-homogenous annotation. To address these issues, we have performed a complete re-annotation of public microarray data from human skeletal muscle biopsies and constructed a muscle expression compendium consisting of nearly 3000 samples. The created muscle compendium is a publicly available resource including all curated annotation. Using this data set, we aimed to elucidate the molecular mechanism of muscle aging and to describe how physical exercise may alleviate negative physiological effects.

U2 - 10.1186/s13395-015-0059-1

DO - 10.1186/s13395-015-0059-1

M3 - Article

VL - 5

JO - Skeletal Muscle

JF - Skeletal Muscle

SN - 2044-5040

M1 - 35

ER -