A novel cytotoxic terpenoid from the flowers of Kaunia lasiophthalma Griseb

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Abstract

A phytochemical study of the flowers of Kaunia lasiophthalma G. (Asteraceae) yielded a novel triterpene (1) together with several known sesquiterpenoids. The structure of the new compound was elucidated by analysis of the spectroscopic data. The biosynthetic origin of 1 is proposed to be a dimerization of an oxidized derivative (3) of the germacrane sesquiterpene costunolide (2), also present in the flowers. The anticancer activity of 1 in the five breast cancer cell lines HCC1937, JIMT-1, L56Br-C1, MCF-7 and SK-BR-3 was compared with the cytotoxicity in the normal-like breast epithelial cell line MCF-10A. 1 exhibited high cytotoxicity in all investigated cancer cell lines with IC50 values ranging from 0.67 to 7.0 mu M, although it is lacking selectivity as the MCF-10A cells were almost as sensitive. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Chemical Sciences
  • Zoology

Keywords

  • Terpenoid, Structure elucidation, In vitro anticancer, Cytotoxicity
Original languageEnglish
Pages (from-to)105-108
JournalPhytochemistry Letters
Volume8
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes