A novel diffusible substance can overcome the apparent AbrB repression of the Bacillus subtilis fatR promoter

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Abstract

In this work we present evidence for a novel diffusible extracellular factor that modulates gene expression in Bacillus subtilis. The factor was found when studying the regulation of the fatR-cyp102A3 operon. In a Spo0A(-) mutant expression of the fatR-cyp102A3 operon was almost abolished. The fatR-cyp102A3 expression defect of a Spo0A(-) mutant could be overcome either by a mutation in the abrB gene or by a diffusible substance excreted by wild-type, abrB mutant and abrB-spo0A double mutant strains.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area

Keywords

  • Cytochrome P450, AbrB, FatR, Bacillus subtilis
Original languageEnglish
Pages (from-to)197-202
JournalFEMS Microbiology Letters
Volume199
Issue number2
Publication statusPublished - 2001
Publication categoryResearch
Peer-reviewedYes