A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon

Research output: Contribution to journalArticle


Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.


External organisations
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medicinal Chemistry


  • *Prostatic Secretory Proteins, *Multigene Family, Molecular Sequence Data, Male, Humans, Guinea Pigs, Gonadal Steroid Hormones/genetics, *Exons, Molecular, *Evolution, Dna, Conserved Sequence, Animals, Base Sequence, Proteins/*genetics, Rats, Research Support, Non-U.S. Gov't, *Semen, Seminal Plasma Proteins, Seminal Vesicle Secretory Proteins, Sequence Homology, Nucleic Acid
Original languageEnglish
Pages (from-to)53-6
JournalFEBS Letters
Issue number1
Publication statusPublished - 1995
Publication categoryResearch

Bibliographic note