A novel method for downstream characterization of breast cancer circulating tumor cells following CellSearch isolation.

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Abstract

Enumeration of circulating tumor cells (CTCs) obtained from minimally invasive blood samples has been well established as a valuable monitoring tool in metastatic and early breast cancer, as well as in several other cancer types. The gold standard technology for detecting CTCs in blood against a backdrop of millions of leukocytes is the FDA-approved CellSearch system (Janssen Diagnostics), which relies on EpCAM-based immunomagnetic separation. Secondary characterization of these cells could enable treatment selection based on specific targets in these cells, as well as providing a real time window into the metastatic process and offering unique insights into tumor heterogeneity. The objective of this study was to develop a method for downstream characterization of CTCs following isolation with the CellSearch system.

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  • Cancer and Oncology
Original languageEnglish
Article number126
JournalJournal of Translational Medicine
Volume13
Issue number1
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

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