A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus

Research output: Contribution to journalArticle


Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). Methods: PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (VT), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used. Results: For controls, the correlation between hippocampal and CP VT was significantly reduced after using PVC along with an eroded VOI (r2 = 0.59, slope = 0.80 versus r2 = 0.15, slope = 0.15; difference: p < 0.05). The same was true for AD patients (p < 0.05). Conclusion: PVC together with an optimized hippocampal VOI resulted in effective reduction of CP spill-in and improved accuracy of hippocampal VT.


  • Emma E. Wolters
  • Sandeep S.V. Golla
  • Tessa Timmers
  • Rik Ossenkoppele
  • Chris W.J. van der Weijden
  • Philip Scheltens
  • Lothar Schwarte
  • Robert C. Schuit
  • Albert D. Windhorst
  • Frederik Barkhof
  • Maqsood Yaqub
  • Adriaan A. Lammertsma
  • Ronald Boellaard
  • Bart N.M. van Berckel
External organisations
  • Amsterdam UMC - Vrije Universiteit Amsterdam
  • University College London
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
  • Radiology, Nuclear Medicine and Medical Imaging
Original languageEnglish
Article number79
JournalEJNMMI Research
Publication statusPublished - 2018
Publication categoryResearch