A novel tool to assess the quality of RWE to guide the management of retinal disease

Research output: Contribution to journalReview article

Abstract

Despite the growing importance of real-world evidence (RWE) for guiding clinical decisions in retinal disease, there is currently no widely used guidance available for assessing the quality and relevance of RWE studies in ophthalmology. This paper summarizes the development of a user-friendly tool that facilitates assessment of the quality of available RWE for neovascular age-related macular degeneration (nAMD), diabetic macular oedema (DME) and retinal vein occlusion (RVO). A literature search was conducted to identify tools developed to assess the quality of RWE, in order to identify the most appropriate framework on which to base this tool. The Good Research for Comparative Effectiveness (GRACE) guidelines was chosen for this purpose as it is designed to assess the quality of observational studies and has been extensively validated, including demonstration of strong sensitivity and specificity. The GRACE guidelines were adapted to develop a straightforward tabular tool that allows simple assessment and comparison of the quality of published evidence in retinal disease for researchers and physicians alike, and includes guidance on treatment details, outcome measures, study population, and controlling for bias. The newly developed tool provides a simple method to support assessment of the strength of evidence and certainty of conclusions drawn from RWE in retinal disease, to ensure clinical decision-making is influenced by the highest quality evidence.

Details

Authors
  • Robert P. Finger
  • Vincent Daien
  • James S. Talks
  • Paul Mitchell
  • Tien Y. Wong
  • Taiji Sakamoto
  • Bora M. Eldem
  • Monica Lövestam-Adrian
  • Jean François Korobelnik
External organisations
  • University of Bonn
  • Royal Victoria Infirmary
  • University of Sydney
  • Singapore Eye Research Institute
  • Duke–NUS Medical School
  • Hacettepe University
  • Skåne University Hospital
  • Centre Hospitalier Universitaire de Bordeaux
  • University of Bordeaux
  • Gui De Chauliac Hospital
  • Kagoshima University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Ophthalmology

Keywords

  • checklist, diabetic macular oedema, GRACE, neovascular aged related macular degeneration, real-world evidence, retinal disease, retinal vein occlusion, tool
Original languageEnglish
JournalActa Ophthalmologica
Publication statusE-pub ahead of print - 2020 Dec 28
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes