A pathology atlas of the human cancer transcriptome

Research output: Contribution to journalArticle

Abstract

Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.

Details

Authors
  • Mathias Uhlen
  • Cheng Jiao Zhang
  • Sunjae Lee
  • Evelina Sjöstedt
  • Linn Fagerberg
  • Gholamreza Bidkhori
  • Rui Benfeitas
  • Muhammad Arif
  • Zhengtao Liu
  • Fredrik Edfors
  • Kemal Sanli
  • Kalle von Feilitzen
  • Per Oksvold
  • Emma Lundberg
  • Sophia Hober
  • Peter Nilsson
  • Johanna Sm Mattsson
  • Jochen M. Schwenk
  • Bengt Glimelius
  • Tobias Sjöblom
  • Per-Henrik Edqvist
  • Dijana Djureinovic
  • Patrick Micke
  • Cecilia Lindskog
  • Adil Mardinoglu
  • Fredrik Ponten
Organisations
External organisations
  • KTH Royal Institute of Technology
  • Stockholm University
  • Uppsala University
  • Chalmers University of Technology
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Article numbereaan2507
JournalScience
Volume357
Issue number6352
Publication statusPublished - 2017 Aug 18
Publication categoryResearch
Peer-reviewedYes