A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus

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Abstract

Single-nucleotide polymorphisms (SNPs) in the major histocompatibility complex class II transactivator (MHC2TA) gene encoding the class II transactivator have been associated with multiple sclerosis, rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the prevalence of a relevant variant in Swedish systemic lupus erythematosus (SLE) cohorts to determine whether SLE shares the same MHC2TA susceptibility allele as the other diseases. No differences were observed between cases and control subjects at either the allele or genotype levels. Furthermore, no significant correlations were found when comparing different clinical and serological SLE phenotypes. This particular polymorphism rs3087456 of the MHC2TA gene does not appear to influence genetic susceptibility to SLE in the Swedish population. We conclude that our data support neither allelic nor genotype association between the MHC2TA SNP and SLE.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area
  • Immunology in the medical area
  • Rheumatology and Autoimmunity

Keywords

  • transactivator, class II transactivator, major histocompatibility complex class II, systemic lupus erythematosus
Original languageEnglish
Pages (from-to)412-414
JournalTissue Antigens
Volume70
Issue number5
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes