A Retrospective Study of Aimed Patch Testing with Aqueous Nickel Sulfate Hexahydrate at 30% and 15% in Patients with Dermatitis

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@article{9d2f3ffda6a04e5ba92e8e2d4ecd337e,
title = "A Retrospective Study of Aimed Patch Testing with Aqueous Nickel Sulfate Hexahydrate at 30% and 15% in Patients with Dermatitis",
abstract = "Background Sometimes, patients with a history of metal intolerance react negatively or doubtfully to nickel at patch testing. Objective The aim of the study was to investigate whether aqueous nickel sulfate hexahydrate at 15% and 30% traces more contact allergy than the nickel preparation in the baseline series at 5%. Methods In the period 1995-2015, more than 800 of 16,059 patients with a negative or doubtful patch test reaction to the petrolatum preparation of nickel at 5% on the day 3 reading were additionally tested with aqueous nickel at 15% and/or 30%. Conclusions In this retrospective study with aimed patch testing with aqueous nickel solutions, significantly more (P < 0.001) contact allergy was obtained as compared with the 5% preparation in petrolatum. The 30% solution was significantly better (P < 0.001) than the 15% solution. To demonstrate that patch testing with nickel at 15% or 30% is better than the present testing with 5% requires simultaneous testing with the 3 nickel preparations.",
author = "Magnus Bruze and Monica Hinds{\'e}n and Martin Mowitz",
year = "2018",
month = jul,
day = "1",
doi = "10.1097/DER.0000000000000388",
language = "English",
volume = "29",
pages = "193--195",
journal = "Dermatitis",
issn = "1710-3568",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}