A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain

Research output: Contribution to journalArticle

Abstract

Adult hippocampal neurogenesis is a highly dynamic process in which new cells are born, but only some of which survive. Of late it has become clear that these surviving newborn neurons have functional roles, most notably in certain forms of memory. Conventional methods to look at adult neurogenesis are based on the quantification of the number of newly born neurons using a simple cell counting methodology. However, this type of approach fails to capture the dynamic aspects of the neurogenic process, where neural proliferation, death and differentiation take place continuously and simultaneously. In this paper, we propose a simple mathematical approach to better understand the adult neurogenic process in the hippocampus which in turn will allow for a better analysis of this process in disease states and following drug therapies.

Details

Authors
  • Minee L Choi
  • Faye Begeti
  • Roger A Barker
  • Namho Kim
Organisations
External organisations
  • University of Cambridge
Research areas and keywords

Keywords

  • Journal Article, Research Support, Non-U.S. Gov't
Original languageEnglish
Pages (from-to)517-29
Number of pages13
JournalHippocampus
Volume26
Issue number4
Publication statusPublished - 2016 Apr
Publication categoryResearch
Peer-reviewedYes