A sol-gel integrated dual-readout microarray platform for quantification and identification of prostate-specific antigen

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

Here, we report a sol-gel integrated affinity microarray for on-chip matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), which enables capture and identification of prostate-specific antigen (PSA) in samples. Protein microarray technologies, which involve miniaturizing spots of capture agents (such as antibody and aptamers) on a solid surface, enable multianalyte sensing and high-throughput analysis of protein-protein and protein-ligand interactions. This technique provides high-sensitivity analysis of biomarkers, as well as molecular profiling, and is thus used in the fields of life science, medicine and proteomics [1]. In clinical application, the high sensitive biomarker analysis enables early diagnosis, and prediction of prognosis and the response to treatment [2,3].

Details

Authors
  • S. W. Lee
  • J. H. Lee
  • H. G. Kwon
  • T. Laurell
  • O. C. Jeong
  • S. Kim
Organisations
External organisations
  • University of Tokyo
  • Dongguk University, Seoul
  • Inje University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biochemistry and Molecular Biology
Original languageEnglish
Title of host publicationMHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages2
Volume2018-January
ISBN (Electronic)9781538633144
Publication statusPublished - 2018 Feb 28
Publication categoryResearch
Peer-reviewedYes
Event28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017 - Nagoya, Japan
Duration: 2017 Dec 32017 Dec 6

Conference

Conference28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017
CountryJapan
CityNagoya
Period2017/12/032017/12/06