A Swedish case-control network for studies of drug-induced morbidity - acute pancreatitis

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title = "A Swedish case-control network for studies of drug-induced morbidity - acute pancreatitis",
abstract = "Objective: To evaluate risk factors - notably drugs - for developing acute pancreatitis. Methods: A population-based, case-control study, encompassing 1.4 million inhabitants aged 20-85 years from four regions in Sweden between 1 January 1995 and 31 May 1998. A total of 462 cases were hospitalised in surgical departments with their first episode of acute pancreatitis without previously known biliary stone disease. From a population register, 1781 controls were randomly selected. Information was obtained from medical records and through telephone interviews. Results: Fifty-seven percent of the cases were males. An expert group found evidence for biliary stones in 50{\%} of the cases, alcohol intake in 23{\%}, but in 29{\%} neither of these factors were present. In all, {"}other{"} factors, e.g. drugs, could have contributed to the development of acute pancreatitis in 52{\%} of the cases. In a multivariate analysis, the adjusted odds ratios (ORs) for H-2 antagonists were 2.4 (95{\%} CI 1.2-4.8) for proton pump inhibitors (PPIs), 2.1 (1.2-3.4) for non-steroidal anti-inflammatory drugs (NSAIDs), 2.3 (1.3-4.0) for those derived from acetic acid and 1.9 (1.1-3.2) antibacterials for systemic use. Significant ORs were found for a history of gastrointestinal tract disorders [1.5 (1.1-1.9)] and inflammatory bowel disease (IBD) [3.4 (1.5-7.9)]. Smoking was significantly associated with acute pancreatitis [1.7 (1.2-2.1)] and, for those smoking more than 20 cigarettes per day, the OR was 4.0 (2.27.5). Alcohol in moderate amounts did not increase the risk, but for those drinking more than 420 g alcohol per week the OR was 4.1 (2.2-7.5). Conclusion: In addition to cholelithiasis, smoking and heavy alcohol use, drugs may be an important risk factor for acute pancreatitis.",
keywords = "acute pancreatitis, risk factors, case-control study",
author = "KB Blomgren and A Sundstrom and G Steineck and S Genell and S Sjostedt and BE Wiholm",
year = "2002",
doi = "10.1007/s00228-002-0471-4",
language = "English",
volume = "58",
pages = "275--283",
journal = "European Journal of Clinical Pharmacology",
issn = "1432-1041",
publisher = "Springer",
number = "4",