A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients

Research output: Contribution to journalReview article

Abstract

The aryl alkyl alcohol simple acid ester derivatives (AAASAE) group of fragrance ingredients was critically evaluated for safety following a complete literature search of the pertinent data. For high end users, calculated maximum skin exposures vary widely from 0.01% to 4.17%. AAASAE exhibit a common route of primary metabolism by carboxylesterases resulting in the formation of the simple acid and an aryl alkyl alcohol. They have low acute toxicity. No significant toxicity was observed in repeat-dose toxicity tests. There was no evidence of carcinogenicity of benzyl alcohol when it was administered in the feed; gavage studies resulted in pancreatic carcinogenesis due to the corn oil vehicle. The AAASAE are not mutagenic in bacterial systems or in vitro in mammalian cells, and have little to no in vivo genotoxicity. Reproductive and developmental toxicity data show no indication of adverse effects on reproductive function and NOELs for maternal and developmental toxicity are far in excess of current exposure levels. The AAASAE are generally not irritating or sensitizing at the current levels of exposure. The Panel is of the opinion that there are no safety concerns regarding the AAASAE at the current levels of use and exposure. (C) 2012 Elsevier Ltd. All rights reserved.

Details

Authors
  • D. Belsito
  • D. Bickers
  • Magnus Bruze
  • P. Calow
  • M. L. Dagli
  • A. D. Fryer
  • H. Greim
  • Y. Miyachi
  • J. H. Saurat
  • I. G. Sipes
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology

Keywords

  • Review, Safety, Fragrance ingredients, Aryl alkyl alcohol, Simple acid, ester
Original languageEnglish
Pages (from-to)S269-S313
JournalFood and Chemical Toxicology
Volume50
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes