Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.

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Bibtex

@article{ce2a493c52094e01ae0a05f8f6415bb9,
title = "Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.",
abstract = "BB-Diabetes Prone (BB-DP) rats, a model for endocrine autoimmune diseases, are severely lymphopenic, especially lacking ART2+ regulatory T cells. BB-Diabetes Resistant (DR) rats are not lymphopenic and do not develop autoimmunity. BB-DP and BB-DR rats only differ at the lymphopenia (lyp) gene (iddm2) on chromosome 4. Since BB-DP rats also show aberrancies in the differentiation of dendritic cells (DC) from bone-marrow precursors, we tested the hypothesis that F344 rats congenic for a BB-DP chromosome 4 region (42.5-93.6Mb; including the lyp gene, but also iddm4) display an in vitro DC differentiation different from normal F344 rats. Here we show that the 42.5-93.6Mb BB-DP chromosome 4 region is linked to an increased DC precursor apoptosis, a low MHC class II expression, a reduced IL-10 production and a reduced T cell stimulatory capacity of DC. From our previous report on DC differentiation defects in BB rats (only differing in iddm2) and the present report, we deduce that the abnorma",
keywords = "BB rat, Diabetes, Dendritic cells, lyp gene",
author = "Vinod Sommandas and Rutledge, {Elizabeth A.} and {Van Yserloo}, Brian and Jessica Fuller and {\AA}ke Lernmark and Drexhage, {Hemmo A.}",
year = "2004",
doi = "10.1016/j.jaut.2005.05.002",
language = "English",
volume = "25",
pages = "1--12",
journal = "Journal of Autoimmunity",
issn = "0896-8411",
publisher = "Elsevier",
number = "1",

}