Abnormal auditory brainstem response in the pons region in youth with autism

Research output: Contribution to journalArticle

Abstract

Purpose of the article: Autism spectrum disorder (ASD)is an impairing neurodevelopmental disorder with an unknown etiology. The present study aims to investigate if the auditory brainstem response (ABR)to complex stimuli in children and adolescents diagnosed with ASD can be a possible objective biomarker in autism. Materials and methods: The ABR of 39 youth with ASD (7–18 years)were compared to the ABR of 34 typically developed youth (TD). The ABR consists of seven positive peaks (waves I–VII)that occur during 10 Ms following a sound stimulus. Results: The amplitude of wave III (region 2.5–4.0 Ms)was higher in the ASD group compared to the TD group. The TD males showed a significant lower degree of correlation, between left and right ear compared to the ASD groups and the TD females. Conclusions: Altered auditory processing was evident in the pons region of the brainstem for the ASD group when compared to the TD group. Implications of the findings are discussed in relation to the neurobiology and assessment of autism spectrum disorder in youth.

Details

Authors
Organisations
External organisations
  • University of Gothenburg
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
  • Psychiatry

Keywords

  • ABR, Adolescents, ASD, Biomarker, Children
Original languageEnglish
Pages (from-to)122-125
Number of pages4
JournalNeurology Psychiatry and Brain Research
Volume32
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes