Abnormal peripheral chemokine profile in Huntington's disease.

Research output: Contribution to journalArticle

Abstract

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain and we have previously demonstrated a widespread, progressive innate immune response detectable in plasma throughout the course of HD. In the present work we used multiplex ELISA to quantify levels of chemokines in plasma from controls and subjects at different stages of HD. We found an altered chemokine profile tracking with disease progression, with significant elevations of five chemokines (eotaxin-3, MIP-1β, eotaxin, MCP-1 and MCP-4) while three (eotaxin-3, MIP-1β and eotaxin) showed significant linear increases across advancing disease stages. We validated our results in a separate sample cohort including subjects at different stages of HD. Here we saw that chemokine levels (MCP-1 and eotaxin) correlated with clinical scores. We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD.

Details

Authors
  • Edward Wild
  • Anna Magnusson-Lind
  • Nayana Lahiri
  • Ulrika Krus
  • Michael J Orth
  • Sarah J Tabrizi
  • Maria Björkqvist
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
  • Neurosciences
Original languageEnglish
Article numberRRN1231
JournalPLoS Currents
Volume3
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes

Related research output

Magnusson-Lind, A., 2014, Lund University (Media-Tryck). 182 p.

Research output: ThesisDoctoral Thesis (compilation)

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