Absence of Parallel Fibre to Purkinje Cell LTD During Eyeblink Conditioning

Research output: Contribution to journalArticle


Long-term depression (LTD) of parallel fibre/Purkinje cell synapses has been the favoured explanation for cerebellar motor learning such as classical eyeblink conditioning. Previous evidence against this interpretation has been contested. Here we wanted to test whether a classical conditioning protocol causes LTD. We applied a conditioning protocol, using a train of electrical pulses to the parallel fibres as the conditional stimulus. In order to rule out indirect effects caused by antidromic granule cell activation or output from Purkinje cells that might produce changes in Purkinje cell responsiveness, we focused the analysis on the first pulse in the conditional stimulus, that is, before any indirect effects would have time to occur. Purkinje cells learned to respond with a firing pause to the conditional stimulus. Yet, there was no depression of parallel fibre excitation after training.


External organisations
  • Pompeu Fabra University
  • Linnaeus University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell Biology
  • Neurosciences
  • Cell and Molecular Biology
Original languageEnglish
Article number14777
JournalScientific Reports
Issue number1
Publication statusPublished - 2018 Dec 1
Publication categoryResearch