Acid-base and biochemical stabilization and quality of recovery in male cats with urethral obstruction and anesthetized with propofol or a combination of ketamine and diazepam

Research output: Contribution to journalArticle

Abstract

This study compared acid-base and biochemical changes and quality of recovery in male cats with experimentally induced urethral obstruction and anesthetized with either propofol or a combination of ketamine and diazepam for urethral catheterization. Ten male cats with urethral obstruction were enrolled for urethral catheterization and anesthetized with either ketamine-diazepam (KD) or propofol (P). Lactated Ringer's solution was administered by intravenous (IV) beginning 15 min before and continuing for 48 h after relief of urethral obstruction. Quality of recovery and time to standing were evaluated. The urethral catheter was maintained to measure urinary output. Hematocrit (Hct), total plasma protein (TPP), albumin, total protein (TP), blood urea nitrogen (BUN), creatinine, pH, bicarbonate (HCO3-), chloride, base excess, anion gap, sodium, potassium, and partial pressure of carbon dioxide in mixed venous blood (pvCO2) were measured before urethral obstruction, at start of fluid therapy (0 h), and at subsequent intervals. The quality of recovery and time to standing were respectively 4 and 75 min in the KD group and 5 and 16 min in the P group. The blood urea nitrogen values were increased at 0, 2, and 8 h in both groups. Serum creatinine increased at 0 and 2 h in cats administered KD and at 0, 2, and 8 h in cats receiving P, although the values were above the reference range in both groups until 8 h. Acidosis occurred for up to 2 h in both groups. Acid-base and biochemical stabilization were similar in cats anesthetized with propofol or with ketamine-diazepam. Cats that received propofol recovered much faster, but the ketamine-diazepam combination was shown to be more advantageous when treating uncooperative cats as it can be administered by intramuscular (IM) injection.

Details

Authors
External organisations
  • Federal University of Santa Maria
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Anesthesiology and Intensive Care

Keywords

  • Acid-Base Equilibrium/drug effects, Acidosis, Anesthesia Recovery Period, Anesthesia, Intravenous/veterinary, Anesthetics, Dissociative/administration & dosage, Anesthetics, Intravenous/administration & dosage, Animals, Blood Urea Nitrogen, Cat Diseases/surgery, Cats, Creatinine/blood, Diazepam/administration & dosage, Drug Therapy, Combination, Hyperkalemia, Ketamine/administration & dosage, Male, Propofol/pharmacology, Urethral Obstruction/blood
Original languageEnglish
Pages (from-to)201-8
Number of pages8
JournalCanadian Journal of Veterinary Research
Volume76
Issue number3
Publication statusPublished - 2012 Jul
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes