Acoustophoresis separation of bacteria from blood cells for rapid sepsis diagnostics

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

We present a significantly improved acoustophoresis method to separate bacteria from red and white blood cells. As much as 98% of the bacteria were recovered, while only 0.06 % of the red and white blood cells remained. This 1600-fold relative enrichment was achieved by adjusting the center medium density, tightly controlling the chip temperature and stabilizing the fluid flows. This is a crucial sample preparation step facilitating downstream bacteria identification for sepsis diagnostics.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biomedical Laboratory Science/Technology

Keywords

  • Acoustophoresis, Bacteria, Blood, Sepsis
Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1320-1322
Number of pages3
Volume2
ISBN (Print)9781632666246
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Conference

Conference17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period2013/10/272013/10/31