Activation of maternal Epstein-Barr virus infection and risk of acute leukemia in the offspring

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Activation of maternal Epstein-Barr virus infection and risk of acute leukemia in the offspring. / Tedeschi, Rosamaria; Bloigu, Aini; Ogmundsdottir, Helga M.; Marus, Alessia; Dillner, Joakim; dePaoli, Paolo; Gudnadottir, Margret; Koskela, Pentti; Pukkala, Eero; Lehtinen, Tuula; Lehtinen, Matti.

In: American Journal of Epidemiology, Vol. 165, No. 2, 2007, p. 134-137.

Research output: Contribution to journalArticle

Harvard

Tedeschi, R, Bloigu, A, Ogmundsdottir, HM, Marus, A, Dillner, J, dePaoli, P, Gudnadottir, M, Koskela, P, Pukkala, E, Lehtinen, T & Lehtinen, M 2007, 'Activation of maternal Epstein-Barr virus infection and risk of acute leukemia in the offspring', American Journal of Epidemiology, vol. 165, no. 2, pp. 134-137. https://doi.org/10.1093/aje/kwj332

APA

Tedeschi, R., Bloigu, A., Ogmundsdottir, H. M., Marus, A., Dillner, J., dePaoli, P., ... Lehtinen, M. (2007). Activation of maternal Epstein-Barr virus infection and risk of acute leukemia in the offspring. American Journal of Epidemiology, 165(2), 134-137. https://doi.org/10.1093/aje/kwj332

CBE

Tedeschi R, Bloigu A, Ogmundsdottir HM, Marus A, Dillner J, dePaoli P, Gudnadottir M, Koskela P, Pukkala E, Lehtinen T, Lehtinen M. 2007. Activation of maternal Epstein-Barr virus infection and risk of acute leukemia in the offspring. American Journal of Epidemiology. 165(2):134-137. https://doi.org/10.1093/aje/kwj332

MLA

Vancouver

Author

Tedeschi, Rosamaria ; Bloigu, Aini ; Ogmundsdottir, Helga M. ; Marus, Alessia ; Dillner, Joakim ; dePaoli, Paolo ; Gudnadottir, Margret ; Koskela, Pentti ; Pukkala, Eero ; Lehtinen, Tuula ; Lehtinen, Matti. / Activation of maternal Epstein-Barr virus infection and risk of acute leukemia in the offspring. In: American Journal of Epidemiology. 2007 ; Vol. 165, No. 2. pp. 134-137.

RIS

TY - JOUR

T1 - Activation of maternal Epstein-Barr virus infection and risk of acute leukemia in the offspring

AU - Tedeschi, Rosamaria

AU - Bloigu, Aini

AU - Ogmundsdottir, Helga M.

AU - Marus, Alessia

AU - Dillner, Joakim

AU - dePaoli, Paolo

AU - Gudnadottir, Margret

AU - Koskela, Pentti

AU - Pukkala, Eero

AU - Lehtinen, Tuula

AU - Lehtinen, Matti

PY - 2007

Y1 - 2007

N2 - After identifying an association between maternal Epstein-Barr virus (EBV) reactivation and acute lymphoblastic leukemia (ALL), the authors analyzed a nested case-control study within Finnish and Icelandic maternity cohorts with 7 million years of follow-up to confirm EBV's role in ALL. Offspring of 550,000 mothers were followed up to age 15 years during 1975-1997 by national cancer registries to identify leukemia cases. Mothers of cases and three quarters of matched mothers of controls were identified by national population registers. First-trimester sera from mothers of 304 ALL cases and 39 non-ALL cases and from 943 mothers of controls were analyzed for antibodies to viral capsid antigen, early antigen, and EBV transactivator protein ZEBRA. Relative risk, estimated as odds ratio (95% confidence interval), was adjusted for birth order and sibship size. Combining early antigen and/or ZEBRA immunoglobulin G antibodies with the presence of viral capsid antigen immunoglobulin M antibodies did not increase the estimate for ALL risk for viral capsid antigen immunoglobulin M alone (odds ratio = 1.9, 95% confidence interval: 1.2, 3.0). Both ZEBRA immunoglobulin G antibodies and viral capsid antigen immunoglobulin M antibodies were associated with an increased risk of non-ALL in the offspring (odds ratio = 4.5, 95% confidence interval: 1.3, 16; odds ratio = 5.6, 95% confidence interval: 1.1, 29, respectively), suggesting EBV reactivation in the mothers of non-ALL cases. EBV reactivation may be associated with a proportion of childhood leukemia.

AB - After identifying an association between maternal Epstein-Barr virus (EBV) reactivation and acute lymphoblastic leukemia (ALL), the authors analyzed a nested case-control study within Finnish and Icelandic maternity cohorts with 7 million years of follow-up to confirm EBV's role in ALL. Offspring of 550,000 mothers were followed up to age 15 years during 1975-1997 by national cancer registries to identify leukemia cases. Mothers of cases and three quarters of matched mothers of controls were identified by national population registers. First-trimester sera from mothers of 304 ALL cases and 39 non-ALL cases and from 943 mothers of controls were analyzed for antibodies to viral capsid antigen, early antigen, and EBV transactivator protein ZEBRA. Relative risk, estimated as odds ratio (95% confidence interval), was adjusted for birth order and sibship size. Combining early antigen and/or ZEBRA immunoglobulin G antibodies with the presence of viral capsid antigen immunoglobulin M antibodies did not increase the estimate for ALL risk for viral capsid antigen immunoglobulin M alone (odds ratio = 1.9, 95% confidence interval: 1.2, 3.0). Both ZEBRA immunoglobulin G antibodies and viral capsid antigen immunoglobulin M antibodies were associated with an increased risk of non-ALL in the offspring (odds ratio = 4.5, 95% confidence interval: 1.3, 16; odds ratio = 5.6, 95% confidence interval: 1.1, 29, respectively), suggesting EBV reactivation in the mothers of non-ALL cases. EBV reactivation may be associated with a proportion of childhood leukemia.

KW - case-control studies

KW - antibodies

KW - child

KW - Epstein-Barr virus infections

KW - Iceland

KW - Finland

KW - leukemia

KW - lymphocytic

KW - acute

U2 - 10.1093/aje/kwj332

DO - 10.1093/aje/kwj332

M3 - Article

VL - 165

SP - 134

EP - 137

JO - American journal of hygiene

JF - American journal of hygiene

SN - 0002-9262

IS - 2

ER -