Activities of daily living - Outcome during two years in galantamine treated Alzheimer patients

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

122 patients with Alzheimer's disease receiving galantamine in the Swedish Alzheimer Treatment Study were studied with respect to longitudinal change in cognition (MMSE and ADAS-cog) and function (IADL, PSMS and FAST). Particularly the FAST mean change from baseline showed a linear relationship with cognitive mean change and the strength of the relationship increased over time. The IADL scale demonstrated a faster decline of function, but significantly less than expected by using the mathematical model by Green et al. A cluster analysis was performed to reveal any natural groupings of the patients based on the functional scores at baseline. The two-cluster solution was significant; patients in cluster 1 were more cognitively impaired at baseline, they were less apt to carry the APOE e4 allele and declined faster in the outcome of PSMS score compared to the other group.

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Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Title of host publicationNew Trends in Alzheimer and Parkinson Related Disorders: ADPD 2007
PublisherMedimond
Pages251-255
ISBN (Print)978-88-7587-405-6
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedNo
Event8th International Conference on Alzheimer`s and Parkinson`s Diseases (AD/PD 2007) - Salzburg, Austria
Duration: 2007 Mar 142007 Mar 18

Conference

Conference8th International Conference on Alzheimer`s and Parkinson`s Diseases (AD/PD 2007)
CountryAustria
CitySalzburg
Period2007/03/142007/03/18

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