Acute lung injury and ARDS in acute pancreatitis: Mechanisms and potential intervention

Research output: Contribution to journalArticle

Abstract

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis still represents a substantial problem, with a mortality rate in the range of 30%-40%. The present review evaluates underlying pathophysiological mechanisms in both ALI and ARDS and potential clinical implications. Several mediators and pathophysiological pathways are involved during the different phases of ALI and ARDS. The initial exudative phase is characterized by diffuse alveolar damage, microvascular injury and influx of inflammatory cells. This phase is followed by a fibro-proliferative phase with lung repair, type II pneumocyte hypoplasia and proliferation of fibroblasts. Proteases derived from polymorphonuclear neutrophils, various pro-inflammatory mediators, and phospholipases are all involved, among others. Contributing factors that promote pancreatitis-associated ALI may be found in the gut and mesenteric lymphatics. There is a lack of complete understanding of the underlying mechanisms, and by improving our knowledge, novel tools for prevention and intervention may be developed, thus contributing to improved outcome. (C) 2010 Baishideng. All rights reserved.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Gastroenterology and Hepatology

Keywords

  • Pathophysiology, pancreatitis, Etiology, Acute, Acute lung injury, Acute respiratory distress syndrome
Original languageEnglish
Pages (from-to)2094-2099
JournalWorld Journal of Gastroenterology
Volume16
Issue number17
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes