Acute plateletpheresis and aprotinin reduces the need for blood transfusion following Ross operation.

Research output: Contribution to journalArticle


The effect of acute intraoperative plateletpheresis (25% platelet yield) in combination with intraoperative low-dose aprotinin (2 million units) on blood conservation was investigated in 18 young adult patients undergoing elective Ross operation. The results were compared with a group of 19 similar patients without plateletpheresis (control group). The hematological and coagulation parameters at admission and discharge were statistically similar in both groups. The total blood product transfusion requirements were significantly reduced in the plateletpheresis group compared with the control group (3.2 units and 5.1 units, respectively, P=0.036). The total blood donor exposure was also reduced significantly in the plateletpheresis group compared with the control group (3.2 and 6.9 donors/patient, respectively, P<0.001). The direct costs for the hospital for the plateletpheresis procedure, including costs for all blood products, were similar to those for blood products alone in the control group. In summary, acute plateletpheresis in combination with low-dose aprotinin significantly reduces the blood product transfusions and blood donor exposures following the Ross operation; the treatment is cost-effective.


External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Clinical Medicine
Original languageEnglish
Pages (from-to)618-622
JournalInteractive Cardiovascular and Thoracic Surgery
Issue number5
Early online date2007 Jul 25
Publication statusPublished - 2007
Publication categoryResearch
Externally publishedYes

Related research output

Alrashidi, F., 2010, Heart and Lung division, Faculty of Medicine. 150 p.

Research output: ThesisDoctoral Thesis (compilation)

View all (1)