Advances in stem cell research and therapeutic development

Research output: Contribution to journalReview article


Despite many reports of putative stem-cell-based treatments in genetic and degenerative disorders or severe injuries, the number of proven stem cell therapies has remained small. In this Review, we survey advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials. Finally, we analyse the scientific rationale, experimental approaches, caveats and results underpinning the clinical use of such stem cells.


  • Michele De Luca
  • Alessandro Aiuti
  • Giulio Cossu
  • Malin Parmar
  • Graziella Pellegrini
  • Pamela Gehron Robey
External organisations
  • University of Modena and Reggio Emilia
  • Vita-Salute San Raffaele University
  • University of Manchester
  • National Institute of Dental and Craniofacial Research
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology
Original languageEnglish
Pages (from-to)801-811
Number of pages11
JournalNature Cell Biology
Issue number7
Publication statusPublished - 2019
Publication categoryResearch