Age dependence of renal function: clearance of iohexol and p-amino hippurate in healthy males

Research output: Contribution to journalArticle

Abstract

Iohexol, a newly developed non-ionic contrast agent, has been recently documented as a reliable glomerular filtration marker. This study describes the age dependence of the single injection clearance of iohexol in a sample of healthy male volunteers ranging from 21 to 77 years of age. In parallel, renal plasma flow was studied by measuring the total clearance of p-amino hippuric acid administered as a continuous infusion. In subjects older than 50 years a negative correlation to age was found for both p-amino hippuric acid and iohexol clearance, with a reduction of 52 ml/min and 12 ml/min per decade, respectively, whereas no age dependence was found for younger subjects. Correlation between p-amino hippuric acid and iohexol clearances was 0.81. However, the filtration fraction, defined as the ratio of iohexol to p-amino hippuric acid clearance, was higher in the elderly subjects. A consistent discrepancy was found between total and renal clearances of p-amino hippuric acid, indicating significant renal metabolism. Renal clearance of creatinine was poorly correlated to iohexol clearance and did not show any relationship to age.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine
  • Pharmacology and Toxicology
  • Medicinal Chemistry

Keywords

  • iohexol clearance, p-amino hippurate clearance, renal plasma flow, creatinine clearance, glomerular filtration rate, aged, age dependence
Original languageEnglish
Pages (from-to)641-646
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume49
Issue number7
Publication statusPublished - 1989
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000), Division of Clinical Chemistry and Pharmacology (013250300)