Age governs gender-dependent islet cell autoreactivity and predicts the clinical course in childhood IDDM

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Age governs gender-dependent islet cell autoreactivity and predicts the clinical course in childhood IDDM. / Örtqvist, E.; Falorni, A.; Scheynius, A.; Persson, B.; Lernmark, Å.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 86, No. 11, 01.01.1997, p. 1166-1171.

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T1 - Age governs gender-dependent islet cell autoreactivity and predicts the clinical course in childhood IDDM

AU - Örtqvist, E.

AU - Falorni, A.

AU - Scheynius, A.

AU - Persson, B.

AU - Lernmark, Å

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Most IDDM patients temporarily restore some of their beta-cell function following the initiation of insulin therapy. The aim of this study was to analyse the influence of age, gender, metabolic state at diagnosis and presence of autoantibodies (GAD65 antibodies and ICA) on the duration of the clinical partial remission. In total, 149 consecutively diagnosed IDDM children, 0-16 y old (70F, 79M, mean age 9.5 y) were studied. Partial remission was arbitrarily defined as the period when the insulin dose was below 0.5 U/BW 24 h-1 and HbA1c below 7.5%, and occurred in 119/149 patients with a duration between 1 and 38 months. Cox's regression analysis showed that the factors significantly associated with the duration of remission were age, gender, interaction between age and gender, ICA and a high initial HbA1c, whereas GAD65Ab had no influence. Young boys had the shortest remission period, while adolescent boys had the longest, as compared to young and adolescent girls. The ICA-negative patients (n = 42) had a longer remission period (median 9.7 months) than the ICA-positive children (n = 107; 5.0 months;p = 0.0001), regardless of GAD65Ab status. We speculate that the relative insulin resistance, which is more pronounced in pubertal girls than in boys, may be associated with a more rapid increase of exogenous insulin requirement. These findings are important when evaluating the effect of islet cell autoreactivity on the clinical course of IDDM in children.

AB - Most IDDM patients temporarily restore some of their beta-cell function following the initiation of insulin therapy. The aim of this study was to analyse the influence of age, gender, metabolic state at diagnosis and presence of autoantibodies (GAD65 antibodies and ICA) on the duration of the clinical partial remission. In total, 149 consecutively diagnosed IDDM children, 0-16 y old (70F, 79M, mean age 9.5 y) were studied. Partial remission was arbitrarily defined as the period when the insulin dose was below 0.5 U/BW 24 h-1 and HbA1c below 7.5%, and occurred in 119/149 patients with a duration between 1 and 38 months. Cox's regression analysis showed that the factors significantly associated with the duration of remission were age, gender, interaction between age and gender, ICA and a high initial HbA1c, whereas GAD65Ab had no influence. Young boys had the shortest remission period, while adolescent boys had the longest, as compared to young and adolescent girls. The ICA-negative patients (n = 42) had a longer remission period (median 9.7 months) than the ICA-positive children (n = 107; 5.0 months;p = 0.0001), regardless of GAD65Ab status. We speculate that the relative insulin resistance, which is more pronounced in pubertal girls than in boys, may be associated with a more rapid increase of exogenous insulin requirement. These findings are important when evaluating the effect of islet cell autoreactivity on the clinical course of IDDM in children.

KW - Autoantibodies

KW - Childhood IDDM

KW - Clinical remission

KW - GAD65Ab

KW - ICA

U2 - 10.1111/j.1651-2227.1997.tb14837.x

DO - 10.1111/j.1651-2227.1997.tb14837.x

M3 - Article

C2 - 9401507

AN - SCOPUS:0030716341

VL - 86

SP - 1166

EP - 1171

JO - Acta Pædiatrica

JF - Acta Pædiatrica

SN - 1651-2227

IS - 11

ER -