Ag−Polymer nanocomposites for capture, detection, and destruction of bacteria

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Abstract

Bacterial infection is one of the major problems for human health. To prevent outbreak of bacteria-caused diseases, early diagnosis of bacterial pathogen and effective destruction of pathogenic microorganisms are in urgent need. In this work, we developed a new multifunctional nanocomposite material that can effectively capture and destroy bacteria. Epoxide-modified nanoparticles were synthesized by microemulsion polymerization and precipitation polymerization. The epoxide groups on the particle surface were reacted with polyethylenimine to introduce cationic amine groups. The amine groups on the nanoparticle surface enhanced the colloidal stability of the particles’ suspension and provided multivalent interactions to bind and destroy the bacteria. After further modification with Ag nanoparticles, the final composite nanomaterial was able to not only capture and destroy Gram-negative bacteria but also allow the bacteria’s fingerprint spectra to be obtained through surface-enhanced Raman scattering.
The multifunctional nanoparticles developed in this work offer a new approach toward fast capture, detection, and destruction of pathogenic bacteria.

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Subject classification (UKÄ) – MANDATORY

  • Natural Sciences

Keywords

  • Raman enhancement, Ag nanoparticles, nanocomposites, antibacterial, polymer nanoparticles, polyethylenimine
Original languageEnglish
Pages (from-to)1655−1663
JournalACS Applied Nano Materials
Volume2
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes

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