Airway epithelial repair: breathtakingly quick and multipotentially pathogenic

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Airway epithelial repair: breathtakingly quick and multipotentially pathogenic. / Erjefält, Jonas; Persson, Carl.

In: Thorax, Vol. 52, No. 11, 1997, p. 1010-1012.

Research output: Contribution to journalArticle

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TY - JOUR

T1 - Airway epithelial repair: breathtakingly quick and multipotentially pathogenic

AU - Erjefält, Jonas

AU - Persson, Carl

PY - 1997

Y1 - 1997

N2 - Epithelial shedding, even to the point of airway denudation, had already been described as a common and unifying feature of asthma by the latter half of the 19th century. However, the repair processes that specifically follow the shedding-like loss of epithelial cells have only recently been examined in vivo. This paper discusses the exceedingly fast epithelial restitution and the potential pathogenic sequelae to epithelial shedding alone that have been unravelled. Epithelial cytoprotection emerges as an important property of future therapeutic drugs for the treatment of airways inflammatory conditions.

AB - Epithelial shedding, even to the point of airway denudation, had already been described as a common and unifying feature of asthma by the latter half of the 19th century. However, the repair processes that specifically follow the shedding-like loss of epithelial cells have only recently been examined in vivo. This paper discusses the exceedingly fast epithelial restitution and the potential pathogenic sequelae to epithelial shedding alone that have been unravelled. Epithelial cytoprotection emerges as an important property of future therapeutic drugs for the treatment of airways inflammatory conditions.

KW - asthma pathology

KW - mucosal barrier

KW - epithelial repair

M3 - Article

VL - 52

SP - 1010

EP - 1012

JO - Thorax

T2 - Thorax

JF - Thorax

SN - 1468-3296

IS - 11

ER -