Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.

Research output: Contribution to journalArticle

Abstract

Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway inflammation. It is unknown how AHR to mannitol relates to mast cell phenotype, mast cell function and measures of eosinophilic inflammation in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell associated genes and number of eosinophils in airway tissue of subjects with asthma and healthy controls in relation to AHR to mannitol.

Details

Authors
  • Asger Sverrild
  • Anders Bergqvist
  • Katherine J Baines
  • Celeste Porsbjerg
  • Cecilia Andersson
  • Simon Francis Thomsen
  • Hans Jürgen Hoffmann
  • Peter Gibson
  • Jonas Erjefält
  • Vibeke Backer
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Respiratory Medicine and Allergy
Original languageEnglish
Pages (from-to)288-297
JournalClinical and Experimental Allergy
Volume46
Issue number2
Early online date2015 Aug 7
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes