Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor

Research output: Contribution to journalArticle

Abstract

Background: Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks. Objectives: To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen. Patients and Methods: Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre. All but 1 were patch tested with a baseline series, and with pieces and/or ultrasonic bath extracts of (the adhesive part of) the glucose sensor. Isobornyl acrylate was patch tested, in various concentrations and vehicles, in 13 patients. Gas chromatography–mass spectrometry (GC-MS) of the sensors was performed. Results: All patients reacted to the adhesive part of the sensor, and 12 patients were shown to be sensitized to isobornyl acrylate. Simultaneous reactions to other allergens were rarely observed. GC-MS showed the presence of isobornyl acrylate in the sensors. Conclusions: Cases of allergic contact dermatitis caused by FreeStyle® Libre are increasingly being observed, and isobornyl acrylate is a relevant culprit allergen. Cross-reactivity to other acrylates was infrequently observed, but other, hitherto unidentified, contact allergens may still be present in the device.

Details

Authors
Organisations
External organisations
  • Saint-Luc University Hospital
  • Antwerp University Hospital
  • Skåne University Hospital
  • University Hospitals Leuven
  • University of Antwerp
  • Catholic University of Leuven
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Dermatology and Venereal Diseases

Keywords

  • acrylates, adhesive, allergic contact dermatitis, CAS no. 5888-33-5, diabetes mellitus, FreeStyle® Libre, gas chromatography, glucose sensor, isobornyl acrylate, mass spectrometry, medical device, sesquiterpene lactone mix
Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalContact Dermatitis
Volume77
Issue number6
Publication statusPublished - 2017 Dec 1
Publication categoryResearch
Peer-reviewedYes