Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease

Research output: Contribution to journalArticle


Objectives: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). Conclusions: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein's role in disease progression and long-term outcomes are needed. (C) 2014 International Parkinson and Movement Disorder Society


  • Sun Ju Chung
  • Joanna M. Biernacka
  • Sebastian M. Armasu
  • Kari Anderson
  • Roberta Frigerio
  • Jan O. Aasly
  • Grazia Annesi
  • Anna Rita Bentivoglio
  • Laura Brighina
  • Marie-Christine Chartier-Harlin
  • Stefano Goldwurm
  • Georgios Hadjigeorgiou
  • Barbara Jasinska-Myga
  • Beom Seok Jeon
  • Yun Joong Kim
  • Rejko Krueger
  • Suzanne Lesage
  • Katerina Markopoulou
  • George Mellick
  • Karen E. Morrison
  • Eng-King Tan
  • David Crosiers
  • Jessie Theuns
  • Christine Van Broeckhoven
  • Karin Wirdefeldt
  • Zbigniew K. Wszolek
  • Alexis Elbaz
  • Demetrius M. Maraganore
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology


  • Parkinson's disease, alpha-synuclein, gene, survival, association
Original languageEnglish
Pages (from-to)1053-1057
JournalMovement Disorders
Issue number8
Publication statusPublished - 2014
Publication categoryResearch