Alteration of putaminal fractional anisotropy in Parkinson’s disease: a longitudinal diffusion kurtosis imaging study

Research output: Contribution to journalArticle

Standard

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - Alteration of putaminal fractional anisotropy in Parkinson’s disease

T2 - Neuroradiology

AU - Surova, Yulia

AU - Nilsson, Markus

AU - Lampinen, Björn

AU - Lätt, Jimmy

AU - Hall, Sara

AU - Widner, Håkan

AU - van Westen, Danielle

AU - Hansson, Oskar

PY - 2018

Y1 - 2018

N2 - Purpose: In Parkinson’s disease (PD), pathological microstructural changes occur that may be detected using diffusion magnetic resonance imaging (dMRI). However, there are few longitudinal studies that explore the effect of disease progression on diffusion indices. Methods: We prospectively included 76 patients with PD and 38 healthy controls (HC), all of whom underwent diffusion kurtosis imaging (DKI) as part of the prospective Swedish BioFINDER study at baseline and 2 years later. Annualized rates of change in DKI parameters, including fractional anisotropy (FA), mean diffusivity (MD), and mean kurtosis (MK), were estimated in the gray matter (GM) by placing regions of interest (ROIs) in the basal ganglia and the thalamus, and in the white matter (WM) by tract-based spatial statistics (TBSS) analysis. Results: When adjusting for potential confounding factors (age, gender, baseline-follow-up interval, and software upgrade of MRI scanner), only a decrease in FA in the putamen of PD patients (β = − 0.248, P < .01) over 2 years was significantly different from the changes observed in HC over the same time period. This 2-year decrease in FA in the putamen in PD correlated with higher l-dopa equivalent dose at baseline (Spearman’s rho = .399, P < .0001). Conclusion: The study indicates that in PD microstructural changes in the putamen occur selectively over a 2-year period and can be detected with DKI.

AB - Purpose: In Parkinson’s disease (PD), pathological microstructural changes occur that may be detected using diffusion magnetic resonance imaging (dMRI). However, there are few longitudinal studies that explore the effect of disease progression on diffusion indices. Methods: We prospectively included 76 patients with PD and 38 healthy controls (HC), all of whom underwent diffusion kurtosis imaging (DKI) as part of the prospective Swedish BioFINDER study at baseline and 2 years later. Annualized rates of change in DKI parameters, including fractional anisotropy (FA), mean diffusivity (MD), and mean kurtosis (MK), were estimated in the gray matter (GM) by placing regions of interest (ROIs) in the basal ganglia and the thalamus, and in the white matter (WM) by tract-based spatial statistics (TBSS) analysis. Results: When adjusting for potential confounding factors (age, gender, baseline-follow-up interval, and software upgrade of MRI scanner), only a decrease in FA in the putamen of PD patients (β = − 0.248, P < .01) over 2 years was significantly different from the changes observed in HC over the same time period. This 2-year decrease in FA in the putamen in PD correlated with higher l-dopa equivalent dose at baseline (Spearman’s rho = .399, P < .0001). Conclusion: The study indicates that in PD microstructural changes in the putamen occur selectively over a 2-year period and can be detected with DKI.

KW - Diffusion kurtosis imaging

KW - Parkinson’s disease

KW - Tract-based spatial statistics

KW - Tractography

UR - http://www.scopus.com/inward/record.url?scp=85040909610&partnerID=8YFLogxK

U2 - 10.1007/s00234-017-1971-3

DO - 10.1007/s00234-017-1971-3

M3 - Article

VL - 60

SP - 247

EP - 254

JO - Neuroradiology

JF - Neuroradiology

SN - 1432-1920

IS - 3

ER -