Altered behavioural responses and functional recovery in rats following sciatic nerve compression and early vs late decompression

Research output: Contribution to journalArticle


Objective: The aim of the study was to examine sensory behaviour and functional recovery in rats during nerve compression and after decompression. Compression injury is a far more common condition than nerve transection. The condition is characterised by numbness and a tingling/burning sensation, and some patients experience pain and allodynia during compression or after decompression treatment. The aetiology is in many cases unknown. Thus, further studies are of great importance for the understanding of this condition. Methods: In the present study, behavioural responses to tactile stimulation, thermal pain, as well as functional sensorimotor behaviour were investigated in rats before, during severe compression, and after decompression. The sciatic nerve of the rats was experimentally compressed for 3 or 28 days, whereafter surgical release, i.e. decompression, of the nerve was performed and the rats were examined up to ∼9 weeks. Results: An altered behaviour was found in response to compression injury, which is mitigated after early decompression treatment. Conclusions: These findings indicate that early intervention during severe compression injuries is of great importance for recovery and restoration of nerve function and, thus, should have an impact on clinical routines regarding treatment of compression injuries.


External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences


  • allodynia, decompression, hyperalgesia, nerve compression, Nerve injury, pain, sensorimotor behaviour
Original languageEnglish
Pages (from-to)321-330
JournalJournal of Plastic Surgery and Hand Surgery
Issue number6
Publication statusPublished - 2016 Nov
Publication categoryResearch