Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.

Research output: Contribution to journalArticle


Previous work implicated the complement system in adult neurogenesis as well as elimination of synapses in the developing and injured CNS. In the present study, we used mice lacking the third complement component (C3) to elucidate the role the complement system plays in hippocampus-dependent learning and synaptic function. We found that the constitutive absence of C3 is associated with enhanced place and reversal learning in adult mice. Our findings of lower release probability at CA3-CA1 glutamatergic synapses in combination with unaltered overall efficacy of these synapses in C3 deficient mice implicate C3 as a negative regulator of the number of functional glutamatergic synapses in the hippocampus. The C3 deficient mice showed no signs of spontaneous epileptiform activity in the hippocampus. We conclude that C3 plays a role in the regulation of the number and function of glutamatergic synapses in the hippocampus and exerts negative effects on hippocampus-dependent cognitive performance.


  • Marta Perez-Alcazar
  • Jonny Daborg
  • Anna Stokowska
  • Pontus Wasling
  • Andreas Björefeldt
  • Marie Kalm
  • Henrik Zetterberg
  • Karl Carlström
  • Klas Blomgren
  • Christine Ekdahl Clementson
  • Eric Hanse
  • Marcela Pekna
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)154-164
JournalExperimental Neurology
Publication statusPublished - 2014
Publication categoryResearch