Alternatively folded proteins with unexpected beneficial functions

Research output: Contribution to journalArticle


HAMLET (human alpha-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the alternatively folded states. Beginning with the history of its discovery and development, the cellular targets that appear to be strongly correlated with tumour cell death are introduced in the present article.


  • Soyoung Min
  • James Meehan
  • Louise M. Sullivan
  • Nial P. Harte
  • Yongjing Xie
  • Gavin P. Davey
  • Catharina Svanborg
  • Andre Brodkorb
  • Ken Mok
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biochemistry and Molecular Biology


  • alternatively folded protein, bovine alpha-lactalbumin made lethal to, tumour cells (BAMLET), equine lysozyme with oleic acid (ELOA), human, alpha-lactalbumin made lethal to tumour cells (HAMLET), multimeric, alpha-lactalbumin (MAL).
Original languageEnglish
Pages (from-to)746-751
JournalBiochemical Society Transactions
Publication statusPublished - 2012
Publication categoryResearch

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