Alzheimer's disease cerebrospinal fluid biomarkers predict cognitive decline in lewy body dementia

Research output: Contribution to journalArticle

Abstract

Introduction: Alzheimer's disease pathologies are common in dementia with Lewy bodies, but their clinical relevance is not clear. CSF biomarkers amyloid beta 1-42, total tau, and tau phosphorylated at threonine 181 reflect Alzheimer's disease neuropathology antemortem. In PD, low CSF amyloid beta 1-42 predict long-term cognitive decline, but little is known about these biomarkers as predictors for cognitive decline in Lewy body dementia. The aim of this study was to assess whether Alzheimer's disease CSF biomarkers predict cognitive decline in Lewy body dementia. Methods: From a large European dementia with Lewy bodies multicenter study, we analyzed baseline Alzheimer's disease CSF biomarkers and serial MMSE (baseline and 1- and 2-year follow-up) in 100 patients with Lewy body dementia. Linear mixed-effects analyses, adjusted for sex, age, baseline MMSE, and education, were performed to model the association between CSF biomarkers and rate of cognitive decline measured with MMSE. An Alzheimer's disease CSF profile was defined as pathological amyloid beta 1-42 plus pathological total tau or phosphorylated tau. Results: The Alzheimer's disease CSF profile, and pathological levels of amyloid beta 1-42, were associated with a more rapid decline in MMSE (2.2 [P < 0.05] and 2.9 points difference [P < 0.01], respectively). Higher total tau values showed a trend toward association without statistical significance (2.0 points difference; P = 0.064), whereas phosphorylated tau was not associated with decline. Conclusions: Reduced levels of CSF amyloid beta 1-42 were associated with more rapid cognitive decline in Lewy body dementia patients. Future prospective studies should include larger samples, centralized CSF analyses, longer follow-up, and biomarker-pathology correlation.

Details

Authors
  • Carla Abdelnour
  • Inger van Steenoven
  • Elisabet Londos
  • Frédéric Blanc
  • Bjørn Auestad
  • Milica G. Kramberger
  • Henrik Zetterberg
  • Brit Mollenhauer
  • Mercè Boada
  • Dag Aarsland
Organisations
External organisations
  • Barcelona Alzheimer Treatment & Research Center
  • Amsterdam UMC - Vrije Universiteit Amsterdam
  • University of Stavanger
  • University of Gothenburg
  • University College London
  • Karolinska Institutet
  • University of Strasbourg
  • University Hospital Of Strasbourg
  • Stavanger University Hospital
  • University Medical Centre Ljubljana
  • Paracelsus-Elena-Klinik Kassel
  • University Medical Center Göttingen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • cognitive decline, CSF biomarkers, Lewy body dementia
Original languageEnglish
Pages (from-to)1203-1208
Number of pages6
JournalMovement Disorders
Volume31
Issue number8
Publication statusPublished - 2016 Aug 1
Publication categoryResearch
Peer-reviewedYes