γ-aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis

Research output: Contribution to journalArticle

Abstract

Extracellular levels of striatal γ-aminobutyric acid (GABA) and taurine were monitored during insulin-induced hypoglycemia using microdialysis. At the onset of isoelectricity in the electroencephalogram (EEG), a transient 5-fold increase in the levels of GABA occurred. Taurine levels increased 5 min following the onset of isoelectricity and continued to increase during the entire isoelectric period. The results demonstrate that events associated with the onset of isoelectricity during hypoglycemia trigger an increase in extracellular concentrations of GABA and taurine. The discrepancy in time-course of these changes may reflect differences in compartmentation, function and metabolism of the two amino acids.

Details

Authors
Organisations
External organisations
  • Karolinska Institutet
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physiology

Keywords

  • extracellular concentration, hypoglycemia, microdialysis, rat, taurine, γ-aminobutyric acid
Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalNeuroscience Letters
Volume62
Issue number2
Publication statusPublished - 1985 Dec 4
Publication categoryResearch
Peer-reviewedYes