Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening

Research output: Contribution to journalArticle

Abstract

Amorphous drug nanosuspensions are prone to particle growth due to Ostwald ripening. By incorporating a second component of extremely low aqueous solubility, Ostwald ripening can be inhibited. These studies indicate that to inhibit ripening, the drug/inhibitor mixture (in the particles) must form a single phase. The drug/inhibitor mixture can be characterized by the interaction parameter chi using the Bragg-Williams theory, in which single phase mixtures are obtained for chi < 2. The chi parameter can be calculated from the (crystalline) solubility of the drug in the inhibitor, provided the inhibitor is a liquid, and the melting entropy and temperature of the drug.

Details

Authors
  • L Lindfors
  • P Skantze
  • U Skantze
  • M Rasmusson
  • A Zackrisson
  • Ulf Olsson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physical Chemistry
Original languageEnglish
Pages (from-to)906-910
JournalLangmuir
Volume22
Issue number3
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes