Amperometric In Vitro Monitoring of Penetration through Skin Membrane

Research output: Contribution to journalArticle

Abstract

The aim of this study was to demonstrate that penetration of quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane was fixed on the top of chemically modified electrodes and penetration of the appropriate compound was registered as electrode current. The methodology allows the study of penetration from solution as well as from pharmaceutical creams. From real-time measurements of electrode current, fluxes and diffusion coefficients of mentioned compounds in skin membranes have been estimated.

Details

Authors
  • Hala Gari
  • Jadwiga Rembiesa
  • Ignas Masilionis
  • Naida Vreva
  • Birgitta Svensson
  • Torbjorn Sund
  • Henri Hansson
  • Anna Karin Moren
  • Malin Sjöö
  • Marie Wahlgren
  • Johan Engblom
  • Tautgirdas Ruzgas
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • Penetration, Transdermal delivery, Amperometry, Quercetin, Hydrogen, peroxide, Ascorbic acid, Skin membrane
Original languageEnglish
Pages (from-to)111-117
JournalElectroanalysis
Volume27
Issue number1
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004), Cell Pathology (013031400), Food Technology (011001017)