Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project

Research output: Contribution to journalArticle

Abstract

We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [ 18 F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [ 18 F]florbetapir binding potential (BP ND ), and we performed linear mixed models to assess the relationships between global [ 18 F]florbetapir BP ND and neuropsychological performance. Higher [ 18 F]florbetapir BP ND was related to lower concurrent Mini-Mental State Examination (β ± SE: −1.69 ± 0.63 p < 0.01) and to steeper rate of decline on tasks capturing memory (Rey Auditory Verbal Learning Task immediate [β ± SE −1.81 ± 0.81, p < 0.05] and delayed recall [β ± SE −1.19 ± 0.34, p < 0.01]), attention/executive functions (Stroop II [color] [β ± SE −0.02 ± 0.01, p < 0.05], Stroop III [word-color] [β ± SE −0.03 ± 0.02, p < 0.05]), and language (category fluency [β ± SE −0.04 ± 0.01, p < 0.01]). These findings suggest that higher amyloid-β load in cognitively normal individuals with subjective cognitive decline from a memory clinic is associated with lower concurrent global cognition and with faster rate of decline in a variety of cognitive domains.

Details

Authors
  • Tessa Timmers
  • Rik Ossenkoppele
  • Sander C.J. Verfaillie
  • Chris W.J. van der Weijden
  • Rosalinde E.R. Slot
  • Linda M.P. Wesselman
  • Albert D. Windhorst
  • Emma E. Wolters
  • Maqsood Yaqub
  • Niels D. Prins
  • Adriaan A. Lammertsma
  • Philip Scheltens
  • Wiesje M. van der Flier
  • Bart N.M. van Berckel
Organisations
External organisations
  • Academic Medical Center
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Amyloid-β, Cognition, Positron emission tomography (PET), Preclinical Alzheimer's disease, Subjective cognitive decline (SCD)
Original languageEnglish
Pages (from-to)50-58
Number of pages9
JournalNeurobiology of Aging
Volume79
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes