Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project

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@article{068ca9c08d3e4e55877ad83a4b974dd1,
title = "Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project",
abstract = "We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44{\%} female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [ 18 F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [ 18 F]florbetapir binding potential (BP ND ), and we performed linear mixed models to assess the relationships between global [ 18 F]florbetapir BP ND and neuropsychological performance. Higher [ 18 F]florbetapir BP ND was related to lower concurrent Mini-Mental State Examination (β ± SE: −1.69 ± 0.63 p < 0.01) and to steeper rate of decline on tasks capturing memory (Rey Auditory Verbal Learning Task immediate [β ± SE −1.81 ± 0.81, p < 0.05] and delayed recall [β ± SE −1.19 ± 0.34, p < 0.01]), attention/executive functions (Stroop II [color] [β ± SE −0.02 ± 0.01, p < 0.05], Stroop III [word-color] [β ± SE −0.03 ± 0.02, p < 0.05]), and language (category fluency [β ± SE −0.04 ± 0.01, p < 0.01]). These findings suggest that higher amyloid-β load in cognitively normal individuals with subjective cognitive decline from a memory clinic is associated with lower concurrent global cognition and with faster rate of decline in a variety of cognitive domains.",
keywords = "Amyloid-β, Cognition, Positron emission tomography (PET), Preclinical Alzheimer's disease, Subjective cognitive decline (SCD)",
author = "Tessa Timmers and Rik Ossenkoppele and Verfaillie, {Sander C.J.} and {van der Weijden}, {Chris W.J.} and Slot, {Rosalinde E.R.} and Wesselman, {Linda M.P.} and Windhorst, {Albert D.} and Wolters, {Emma E.} and Maqsood Yaqub and Prins, {Niels D.} and Lammertsma, {Adriaan A.} and Philip Scheltens and {van der Flier}, {Wiesje M.} and {van Berckel}, {Bart N.M.}",
year = "2019",
doi = "10.1016/j.neurobiolaging.2019.02.020",
language = "English",
volume = "79",
pages = "50--58",
journal = "Neurobiology of Aging",
issn = "1558-1497",
publisher = "Elsevier",

}