An economical biorefinery process for propionic acid production from glycerol and potato juice using high cell density fermentation.

Research output: Contribution to journalArticle


An economically sustainable process was developed for propionic acid production by fermentation of glycerol using Propionibacterium acidipropionici and potato juice, a by-product of starch processing, as a nitrogen/vitamin source. The fermentation was done as high-cell-density sequential batches with cell recycle. Propionic acid production and glycerol consumption rates were dependent on initial biomass concentration, and reached a maximum of 1.42 and 2.30gL(-1)h(-1), respectively, from 50gL(-1) glycerol at initial cell density of 23.7g(CDW)L(-1). Halving the concentration of nitrogen/vitamin source resulted in reduction of acetic and succinic acids yields by ∼39% each. At glycerol concentrations of 85 and 120gL(-1), respectively, 43.8 and 50.8gL(-1) propionic acid were obtained at a rate of 0.88 and 0.29gL(-1)h(-1) and yield of 84 and 78mol%. Succinic acid was 13g% of propionic acid and could represent a potential co-product covering the cost of nitrogen/vitamin source.


Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Industrial Biotechnology
  • Chemical Sciences
Original languageEnglish
Pages (from-to)504-512
JournalBioresource Technology
Publication statusPublished - 2013
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Polymer and Materials Chemistry (LTH) (011001041), Biotechnology (LTH) (011001037)

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Dishisha, T., 2013, 154 p.

Research output: ThesisDoctoral Thesis (compilation)

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