An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

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An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. / Wahlestedt, Martin; Norddahl, Gudmundur; Sten, Gerd; Ugale, Amol; Micha Frisk, Mary-Ann; Mattsson, Ragnar; Deierborg, Tomas; Sigvardsson, Mikael; Bryder, David.

In: Blood, Vol. 121, No. 21, 2013, p. 4257-4264.

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TY - JOUR

T1 - An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

AU - Wahlestedt, Martin

AU - Norddahl, Gudmundur

AU - Sten, Gerd

AU - Ugale, Amol

AU - Micha Frisk, Mary-Ann

AU - Mattsson, Ragnar

AU - Deierborg, Tomas

AU - Sigvardsson, Mikael

AU - Bryder, David

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Stem Cell Center (013041110), Reproductive Immunology (013212062), Stem Cell Aging (013212073), BMC Biomedical Centre (0130322000), Neuroinflammation (013210006)

PY - 2013

Y1 - 2013

N2 - Key points Hematopoietic stem cell aging associate with stable transcriptional alterations that persist through transplantation.Somatic cell reprogramming of aged hematopoietic stem and progenitor cells reverses functional defects associated with hematopoietic aging.

AB - Key points Hematopoietic stem cell aging associate with stable transcriptional alterations that persist through transplantation.Somatic cell reprogramming of aged hematopoietic stem and progenitor cells reverses functional defects associated with hematopoietic aging.

U2 - 10.1182/blood-2012-11-469080

DO - 10.1182/blood-2012-11-469080

M3 - Article

VL - 121

SP - 4257

EP - 4264

JO - Blood

JF - Blood

SN - 1528-0020

IS - 21

ER -