An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin
Research output: Contribution to journal › Article
A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Natural Product Communications|
|Publication status||Published - 2007|
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)