An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

Research output: Contribution to journalArticle


A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.


  • Alberto Pagani
  • Federica Pollastro
  • Silvia Spera
  • Mauro Ballero
  • Olov Sterner
  • Giovanni Appendino
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry


  • SERCA, Thapsia garganica, neohelmanthicin D, thapsivillosin J, thapsigargin, thapsigargicin
Original languageEnglish
Pages (from-to)637-642
JournalNatural Product Communications
Issue number6
Publication statusPublished - 2007
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)