An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes

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An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. / Haukvik, Unn Kristin; Saetre, Peter; McNeil, Thomas; Bjerkan, Petr S.; Andreassen, Ole A.; Werge, Thomas; Jonsson, Erik G.; Agartz, Ingrid.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 34, No. 7, 2010, p. 1259-1265.

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Haukvik, Unn Kristin ; Saetre, Peter ; McNeil, Thomas ; Bjerkan, Petr S. ; Andreassen, Ole A. ; Werge, Thomas ; Jonsson, Erik G. ; Agartz, Ingrid. / An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2010 ; Vol. 34, No. 7. pp. 1259-1265.

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TY - JOUR

T1 - An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes

AU - Haukvik, Unn Kristin

AU - Saetre, Peter

AU - McNeil, Thomas

AU - Bjerkan, Petr S.

AU - Andreassen, Ole A.

AU - Werge, Thomas

AU - Jonsson, Erik G.

AU - Agartz, Ingrid

PY - 2010

Y1 - 2010

N2 - Background Smaller hippocampal volume has repeatedly been reported in schizophrenia patients Obstetric complications (OCs) and single nucleotide polymorphism (SNP) variation in schizophrenia susceptibility genes have independently been related to hippocampal volume We investigated putative independent and interaction effects of severe hypoxia-related OCs and variation in four hypoxia-regulated schizophrenia susceptibility genes (BDNF, DTNBP1, GRM3 and NRG1) on hippocampal volume in schizophrenia patients and healthy controls. Methods Clinical assessment, structural MRI scans, and blood samples for genotyping of 32 SNPs were obtained from 54 schizophrenia patients and 53 control subjects Information on obstetric complications was collected from original birth records Results Severe OCs were related to hippocampal volume in both patients with schizophrenia and healthy control subjects Of the 32 SNPs studied, effects of severe OCs on hippocampal volume were associated with allele variation in GRM3 rs13242038, but the interaction effect was not specific for schizophrenia. SNP variation in any of the four investigated genes alone did not significantly affect hippocampal volume. Conclusions. The findings suggest a gene-environment (G x E) interaction between GRM3 gene variants and severe obstetric complications on hippocampus volume, independent of a diagnosis of schizophrenia Due to the modest sample size, the results must be considered preliminary and require replication in independent samples. (C) 2010 Elsevier Inc All rights reserved

AB - Background Smaller hippocampal volume has repeatedly been reported in schizophrenia patients Obstetric complications (OCs) and single nucleotide polymorphism (SNP) variation in schizophrenia susceptibility genes have independently been related to hippocampal volume We investigated putative independent and interaction effects of severe hypoxia-related OCs and variation in four hypoxia-regulated schizophrenia susceptibility genes (BDNF, DTNBP1, GRM3 and NRG1) on hippocampal volume in schizophrenia patients and healthy controls. Methods Clinical assessment, structural MRI scans, and blood samples for genotyping of 32 SNPs were obtained from 54 schizophrenia patients and 53 control subjects Information on obstetric complications was collected from original birth records Results Severe OCs were related to hippocampal volume in both patients with schizophrenia and healthy control subjects Of the 32 SNPs studied, effects of severe OCs on hippocampal volume were associated with allele variation in GRM3 rs13242038, but the interaction effect was not specific for schizophrenia. SNP variation in any of the four investigated genes alone did not significantly affect hippocampal volume. Conclusions. The findings suggest a gene-environment (G x E) interaction between GRM3 gene variants and severe obstetric complications on hippocampus volume, independent of a diagnosis of schizophrenia Due to the modest sample size, the results must be considered preliminary and require replication in independent samples. (C) 2010 Elsevier Inc All rights reserved

KW - Obstetric complications

KW - Hypoxia-regulated genes

KW - GRM3

KW - Hippocampus

KW - Schizophrenia

U2 - 10.1016/j.pnpbp.2010.07.001

DO - 10.1016/j.pnpbp.2010.07.001

M3 - Review article

VL - 34

SP - 1259

EP - 1265

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

T2 - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 7

ER -