An international multicentre study on the allergenic activity of air-oxidized R-limonene.

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Bibtex

@article{914651b9e3d44ffca6a7e57d16311222,
title = "An international multicentre study on the allergenic activity of air-oxidized R-limonene.",
abstract = "Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2-3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 5.2% (range 2.3-12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0-24%). Few irritant reactions were seen. Conclusions. Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed.",
author = "{Br{\aa}red Christensson}, Johanna and Andersen, {Klaus E} and Magnus Bruze and Johansen, {Jeanne D} and Bego{\~n}a Garcia-Bravo and Ana Gim{\'e}nez-Arnau and Chee-Leok Goh and Rosemary Nixon and White, {Ian R}",
year = "2013",
doi = "10.1111/cod.12036",
language = "English",
volume = "68",
pages = "214--223",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Federation of European Neuroscience Societies and Blackwell Publishing Ltd",
number = "4",

}