An international multicentre study on the allergenic activity of air-oxidized R-limonene.

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An international multicentre study on the allergenic activity of air-oxidized R-limonene. / Bråred Christensson, Johanna; Andersen, Klaus E; Bruze, Magnus; Johansen, Jeanne D; Garcia-Bravo, Begoña; Giménez-Arnau, Ana; Goh, Chee-Leok; Nixon, Rosemary; White, Ian R.

In: Contact Dermatitis, Vol. 68, No. 4, 2013, p. 214-223.

Research output: Contribution to journalArticle

Harvard

Bråred Christensson, J, Andersen, KE, Bruze, M, Johansen, JD, Garcia-Bravo, B, Giménez-Arnau, A, Goh, C-L, Nixon, R & White, IR 2013, 'An international multicentre study on the allergenic activity of air-oxidized R-limonene.', Contact Dermatitis, vol. 68, no. 4, pp. 214-223. https://doi.org/10.1111/cod.12036

APA

Bråred Christensson, J., Andersen, K. E., Bruze, M., Johansen, J. D., Garcia-Bravo, B., Giménez-Arnau, A., Goh, C-L., Nixon, R., & White, I. R. (2013). An international multicentre study on the allergenic activity of air-oxidized R-limonene. Contact Dermatitis, 68(4), 214-223. https://doi.org/10.1111/cod.12036

CBE

Bråred Christensson J, Andersen KE, Bruze M, Johansen JD, Garcia-Bravo B, Giménez-Arnau A, Goh C-L, Nixon R, White IR. 2013. An international multicentre study on the allergenic activity of air-oxidized R-limonene. Contact Dermatitis. 68(4):214-223. https://doi.org/10.1111/cod.12036

MLA

Vancouver

Bråred Christensson J, Andersen KE, Bruze M, Johansen JD, Garcia-Bravo B, Giménez-Arnau A et al. An international multicentre study on the allergenic activity of air-oxidized R-limonene. Contact Dermatitis. 2013;68(4):214-223. https://doi.org/10.1111/cod.12036

Author

Bråred Christensson, Johanna ; Andersen, Klaus E ; Bruze, Magnus ; Johansen, Jeanne D ; Garcia-Bravo, Begoña ; Giménez-Arnau, Ana ; Goh, Chee-Leok ; Nixon, Rosemary ; White, Ian R. / An international multicentre study on the allergenic activity of air-oxidized R-limonene. In: Contact Dermatitis. 2013 ; Vol. 68, No. 4. pp. 214-223.

RIS

TY - JOUR

T1 - An international multicentre study on the allergenic activity of air-oxidized R-limonene.

AU - Bråred Christensson, Johanna

AU - Andersen, Klaus E

AU - Bruze, Magnus

AU - Johansen, Jeanne D

AU - Garcia-Bravo, Begoña

AU - Giménez-Arnau, Ana

AU - Goh, Chee-Leok

AU - Nixon, Rosemary

AU - White, Ian R

PY - 2013

Y1 - 2013

N2 - Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2-3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 5.2% (range 2.3-12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0-24%). Few irritant reactions were seen. Conclusions. Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed.

AB - Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2-3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 5.2% (range 2.3-12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0-24%). Few irritant reactions were seen. Conclusions. Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed.

U2 - 10.1111/cod.12036

DO - 10.1111/cod.12036

M3 - Article

C2 - 23510342

VL - 68

SP - 214

EP - 223

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 4

ER -